Monthly Archives: February 2023

Despite the success of GWAS of alcohol use the mechanisms by which these newly identified genetic associations exert their effects are largely unknown. More importantly, alcohol consumption and misuse appear to have distinct genetic architectures . Ever-larger studies, particularly those extending mere … Continue reading →

Our findings support the need for clinical screening for binge drinking behavior given that many adults who engage in binge drinking behavior do not meet criteria for an AUD, as well as psychoeducation and psychosocial interventions targeting the reduction of … Continue reading →

The Family Smoking Prevention and Tobacco Control Act of 2009 banned the use of all natural and artificial compounds characterized as flavors in combustible cigarettes and any of their component parts to eliminate flavored tobacco products that held special appeal in … Continue reading →

Consistent with other studies,a longer history of cigarette smoking predicted worsening respiratory symptoms and decreased chances of improvement, independent of P30D cigarette smoking, underlining the importance of cigarette smoke exposure in the development or worsening of respiratory symptoms. The consequences of … Continue reading →

The other case involved tacalcitol ointment as the inciting agent. In addition, we recently encountered a second case of oral vitamin D-induced acute pancreatitis , which we are currently examining. Early use of substances has been associated with more severe addictions and … Continue reading →

However, college students are a heterogeneous population, and not all require the same level of intervention . To our knowledge, no one has examined the influence of an alcohol intervention on marijuana use when alcohol interventions are provided sequentially in … Continue reading →

There are substantial uncertainties in the risk assessment of odorants, the greatest being how likely it is that the individual odorants monitored actually are the main contributors to the overall odor sensed. Missing the key odorants invalidates the study. OPM … Continue reading →

The scale is 0 to 5 , and extrapolations to 0 are used to predict the ODTC50. This approach has led to good agreement with ODTC50 values from the literature. Another odor-intensity measurement system is used more widely than OPM. ASTM … Continue reading →

Even much slower trains of action potentials result in a buildup of Ca2 in pyramidal cell dendrites. This Ca2 level perfectly correlates with spike frequency ; therefore, it may induce endocannabinoid release in an activity-dependent manner, if coupled to a coincident activation of … Continue reading →

Such an “inverted U” dose-response relationship warrants further investigation but may be explained by the activation of different cannabinoid receptor types, likely possessing distinct agonist sensitivity , or by the dose-dependent engagement of excitatory or inhibitory afferent pathways of the … Continue reading →