Monthly Archives: March 2023

The CAGE-AID has demonstrated validity, with high internal consistency in screening for problematic drug and alcohol use; a cutoff point of 2+ on the CAGE-AID has a sensitivity of 70% and specificity of 85% for identifying individuals with SUDs. Study … Continue reading →

Based on these findings, one could expect to find associations between perinatal hypoxia or severe OCs and hippocampal volume in the healthy controls as well, as we did in a previous study of schizophrenia patients and healthy controls. The hippocampus is, however, … Continue reading →

The substance use dependent behavior variables are constructed from adolescents’ self-reports of their smoking, drinking, and marijuana use levels. We define the smoking, drinking, and marijuana use response category levels based on four considerations: the statistical distribution of each substance use … Continue reading →

Participants were interviewed via video or audio call except in one case, where responses were collected by e-mail. With permission, calls were recorded and transcribed.The analysis began with calculation of descriptive statistics, including the percentage of pharmacies that furnished naloxone identified in … Continue reading →

Additionally, the current study goes beyond the scope of a standard clinical trial: in addition to assessing the effectiveness of the drug in AUD treatment, this study examines biological mechanisms underpinning the treatment, including neural activation to alcohol cues and … Continue reading →

As AM404 does not activate cannabinoid receptors , the effects of this drug were suggested to result from the elevation of endogenous anandamide levels. However, recent findings suggest that AM404 also directly activates the vanilloid VR1 receptor , complicating the identification … Continue reading →

Godlewski and colleagues reported that administration of the peripherally-restricted CB1R inverse agonist, JD5037, reduced the intake of ethanol in wild-type mice; however, it was ineffective in whole-body CB1R- and GHS-R1a-null mice. Ethanol-consuming mice also had elevated levels of the eCB, … Continue reading →

Although the prevalence of a current or lifetime diagnosis of MDD did not differ between WWH and MWH, MDD was an important risk factor of demonstrating Global weaknesses with spared verbal recognition compared to the profile demonstrating only Weakness in motor function. This finding aligns … Continue reading →

People smoke more when they have filters and low-tar cigarettes.And there is some evidence that improved HIV treatments are associated with increases in risky sexual behavior.How might safety testing have such effects? Conceivably, users who were worried about drug quality … Continue reading →

For example, rates of elevated depression among PLWH were similarly high in all age groups. In contrast, only the youngest HIV− group had relatively low rates of elevated depressive symptomology, with higher rates in older cohorts. This is consistent with research … Continue reading →