Author Archives: hemp2022

The two most prominent models to explain the co-use of nicotine and alcohol are: cross reinforcement through the mesolimbic dopamine pathway and cross-tolerance through shared genetic and nicotinic acetylcholine receptor interactions . The first mechanism of comorbidity is cross-reinforcement which is defined … Continue reading →

Activation of PPAR-a in vivo causes an upregulation of the mRNA and protein levels of a number of peroxisome- and nonperoxisome-associated enzymes and structural proteins, including the antioxidant enzymes catalase, superperoxide-dismutase and mediators of the glutathione pathway. In this context, … Continue reading →

The symposium addressed the intricate relationship between epilepsy and other medical conditions. Dr Scott Mintzer kicked off the symposium with his talk “Epilepsy & Heart Disease: Tips for the Consultant.” He identified the impacts of anticonvulsants on the cardiovascular system … Continue reading →

Proposals to equalize these limits would likely spur greater tax revenue collection in certain parts of the state. Thus far, beyond funds earmarked for school construction, marijuana revenue has financed the regulatory apparatus necessary to oversee the state’s growing recreational … Continue reading →

Outlier images were modeled as nuisance covariates. Each outlier image was represented by a single regressor in the GLM, with a 1 for the outlier time point and 0s elsewhere. Time series of all the voxels within each seed were … Continue reading →

This hypothesis ties into a study that assessed “quality of life” based on measures of alcoholism, substance abuse, criminality and a questionnaire in adults with ADHD who had previously been treated with stimulants versus those that had not. This study … Continue reading →

Application of GA to developing na2 tassels enhanced their feminisation, supporting this hypothesis.When considering mutants with pleiotropic phenotypes, it is difficult to ascertain whether we are observing epistasis, additivity, or synergy simply because there may be epistasis for one phenotype, … Continue reading →

By binding to a different, non-competitive allosteric site on the GABAB receptor, PAMs allow endogenous GABA, binding at its original orthosteric site, to retain its potency and efficacy, reducing the risk of tolerance development and side effects. A number of … Continue reading →

Emerging data indicate that e-cig use may adversely affect the pulmonary and cardiovascular systems. Also, limited evidence exists on the potential of e-cigs to cause carcinogenic effects. To date, clinical studies have primarily investigated the acute effects of vaping. By design, … Continue reading →

MANCOVA revealed significant between groups differences in SOPS P, GAF, and the 15-Analyte Index. Post-Hoc analyses using Bonferroni correction revealed that CHR- CTrauma subjects with a history of childhood trauma demonstrated significantly higher SOPS positive symptom scores than CHR- CNoTrauma, … Continue reading →